TS-HDS antibodies were first described by investigators from Washington University in St. Louis (2003) in five patients with painful sensory axonal neuropathy [1]. Further studies by the same group indicated that TS-HDS antibodies were associated with prominent neuropathic pain in the upper extremit...

I thank Dr. @Manousakis for this comprehensive analysis of the data. Here's my skeptical (cynical) take in brief: After 20 years of acknowledging this antibody, the lack of a clear association tells us something. There aren't enough other disease controls and no clear treatment response. I refrain...