What is the interpretation of an IGRA with positive TB wells and negative nil and negative mitogen wells?

We don't see positive controls in most clinical assays. They are run, of course, but hidden from view. The mitogen well is the positive control in the IGRAs. The mitogen used QuantiFERON-TB Gold is, I believe, PHA or phytohemagglutinin. PHA turns on T-cells to indiscriminately. If I remember my mito...

In the setting of acute inflammatory illness, I would interpret the tests results as indeterminate, regardless of the amounts of interferon produced. In an acutely ill immunocompromised patient, the IGRA is often indeterminate, as they have inadequate immune responses. Similarly, a negative TST plac...