Please select the option that best describes you:
Topics:
Dermatology • Atopic Dermatitis
What is the longest interval that you have been able to stretch a biologic before losing efficacy?
Naturally, this is subject a number of factors and is likely patient-dependent. We also recognize that the way clinical trials have been designed lead to shared intervals (ex: tralokinumab and dupilumab sharing q2w intervals).
Please state the biologic and disease state (ex: atopic dermatitis, psoriasis, etc.).
Answer from: at Academic Institution
I'm not sure, but at least one patient is doing well on guselkumab every 6 months.
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Answer from: at Academic Institution
Some biologics have the potential to provide benefit 4-6 months after the last dose. In psoriasis, certainly that probability is highest with the Il-23's than IL-17s and the TNFi's. In AD, IL4/13 inhibitors average 3-4 months though the newest IL-13i has benefit lasting 38 weeks in their withdrawal ...