What is the longest interval that you have been able to stretch a biologic before losing efficacy?

Some biologics have the potential to provide benefit 4-6 months after the last dose. In psoriasis, certainly that probability is highest with the Il-23's than IL-17s and the TNFi's. In AD, IL4/13 inhibitors average 3-4 months though the newest IL-13i has benefit lasting 38 weeks in their withdrawal ...

I'm not sure, but at least one patient is doing well on guselkumab every 6 months.