What is the longest interval that you have been able to stretch a biologic before losing efficacy?
Naturally, this is subject a number of factors and is likely patient-dependent. We also recognize that the way clinical trials have been designed lead to shared intervals (ex: tralokinumab and dupilumab sharing q2w intervals).
Please state the biologic and disease state (ex: atopic dermatitis, psoriasis, etc.).
2 Answers
Mednet MemberInvited Expert
Dermatology · UCONN
Answered on
Some biologics have the potential to provide benefit 4-6 months after the last dose. In psoriasis, certainly that probability is highest with the Il-23's than IL-17s and the TNFi's. In AD, IL4/13 inhibitors average 3-4 months though the newest IL-13i has benefit lasting 38 weeks in their withdrawal arm. Personally, the longest I've had benefit was with Skyrizi where one patient went 10 months before disease recurrence. It is important to recognize that this "increasing doing interval" may render any biological less effective over time.
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Mednet MemberInvited Expert
Dermatology · Wake Forest University
Answered on
I'm not sure, but at least one patient is doing well on guselkumab every 6 months.
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