What is the maximum cumulative anthracycline dose you would administer in a patient with metastatic soft tissue sarcoma who is asymptomatic with good disease control?

It depends. The often-cited 450 mg/m2 cumulative lifetime dose of doxorubicin refers to an increased risk of cardiac toxicity in patients who received bolus doxorubicin (in contrast to a 48-72 hour continuous infusion) without a cardio-protective agent. We typically do not exceed this amount in one ...

I am in general agreement with the recommendations from @Dr. First Last, but there is some additional experience (personal experience, some of it is published but not all) that I would like to add.

There is considerable variability in the cardiac toxicity of doxorubicin, such that under careful moni...