What is the maximum dose of leucovorin that you use with methotrexate?

This question of folinic acid (leucovorin) dosing in the setting of methotrexate use is challenging to answer since the rationale for choosing leucovorin, the side effect prompting its choice and the dose of methotrexate is needed prior to answering the question.

There is no clear literature-based re...

I usually start with folic acid 1 mg daily, however if patient having ongoing side effects from methotrexate, I change to Leucovorin 5 mg weekly and if needed increase upto 10 mg weekly.

It depends on dose of methotrexate and side effects patients experiencing.