What is the optimal approach to managing oral toxicities, such as dysgeusia, caused by immune checkpoint inhibitors (ICIs)?  

Dysgeusia is uncommon with IO and could be related to other issues. Usually, nothing is done, but we wait until the taste buds revive. Sometimes, I recommend zinc lozenges. It could be a "good" placebo.

I would first make sure to check that it’s not due to HSV infection. I've had a few patients who experienced significant mucositis while on ICI, though it’s not a common side effect. I would recommend supportive measures such as using magic mouthwash (containing numbing medicine like lid...