What is the optimal approach to managing oral toxicities, such as dysgeusia, caused by immune checkpoint inhibitors (ICIs)?

Unfortunately, this is a very strange side effect of ICI. I have seen this a few times in my clinic, and mechanistically, in my humble opinion, this is a neurologic irAE. I also notice patients losing tremendous amounts of weight due to the inability to taste and eat food. There is no good fix for t...

Dysgeusia is uncommon with IO and could be related to other issues. Usually, nothing is done, but we wait until the taste buds revive. Sometimes, I recommend zinc lozenges. It could be a "good" placebo.

I would first make sure to check that it’s not due to HSV infection. I've had a few patients who experienced significant mucositis while on ICI, though it’s not a common side effect. I would recommend supportive measures such as using magic mouthwash (containing numbing medicine like lidocaine), pep...