What is the optimal dose and fractionation of RT for a T2N0 laryngeal SCC?  

Particularly the old T2b with sluggish cords and rather diffuse involvement? The data is mixed with regard to hyper- fractionation, vs. hypo-fractionation or standard franc, 9512 does not provide much clarity. I have seen 65.25 at 2.25 Gy per fraction used, but its unclear to me if this is better than hyper-fractionated approaches, however it sure is more convenient for the patient. Is there a optimal approach here? 



Answer from: Radiation Oncologist at Academic Institution