What is the optimal dose and fractionation of RT for a T2N0 laryngeal SCC?
Particularly the old T2b with sluggish cords and rather diffuse involvement? The data is mixed with regard to hyper- fractionation, vs. hypo-fractionation or standard franc, 9512 does not provide much clarity. I have seen 65.25 at 2.25 Gy per fraction used, but its unclear to me if this is better than hyper-fractionated approaches, however it sure is more convenient for the patient. Is there a optimal approach here?
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · University of Texas MD Anderson Cancer Center
Answered on
Great question. The data for accelerated fractionation (AFX) vs. hyperfractionation (HFX) vs. standard fractionation for T2 is a bit difficult to parse.
At a basic level, we all recognize that T2 larynx spans a range from pts just a bit larger than T1 TVC cases, who could expect >90% survival with RT...
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