What is the optimal timing of adjuvant chemotherapy and radiation for a young adult with a grade II oliogodendroglioma?
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In a young adult with G2 oligo, subtotal resection, IDH mutated, would you:
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1 Answer
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Radiation Oncology · Florida International University
Answered on
RTOG 9802 provides a substantial amount of data necessary to answer this question. In patients with residual disease following resection of a G2 oligodendroglioma, I tend to recommend RT and PCV chemotherapy (with my bias being to favor RT prior to PCV).
RTOG 9802 is one of the very few randomized trials in the low grade glioma (WHO G2) domain. In that trial, there was one arm, where surgeon defined gross totally resected patients were prospectively observed. In 2008, we published the results of this "observation" cohort in J Neurosurgery. The 5 year PFS rate for this "gross totally resected" cohort of 111 patients was under 50%, i.e. half progressed within 5 years or less. Although these patients were surgically labeled as GTR, several had ...
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