What is the practical application of alpha-synuclein seed amplification assay CSF testing for the diagnosis and management of Parkinson's disease?
In light of commercially available SYNTap CSF testing.
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How do you use αSyn-SAA in clinical practice?
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2 Answers
Mednet MemberInvited Expert
Neurology · University of Cincinnati
Answered on · Updated on
The α-synuclein seed amplification assay (αSyn-SAA) sensitively identifies patients with Parkinson’s disease from cerebrospinal fluid (CSF) samples. A positive αSyn-SAA is proposed to "biologically define" Parkinson’s disease and anchor disease staging. A positive αSyn-SAA identifies aggregated α-sy...
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Mednet Member
Neurology · Inova Health System
Answered on · Updated on
I use skin biopsies which have good reported sensitivity and specificity to diagnose PD/DLB and MSA (Gibbons et al., PMID 38506839), and anecdotally able to distinguish between PD/DLB and MSA (Gibbons et al., PMID 36657992).
In my practice, I use skin biopsies when the differential includes tardive p...
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