What is the preferred palliative treatment regimen for elderly patients with advanced cholangiocarcinoma?

There is very limited data to provide a data driven approach to the management of elderly patients with advanced cholangiocarcinoma. In my clinical experience, gem/cis combinational chemotherapy as given in the ABC-02 trial is well tolerated for most older adults with preserved performance status an...

I completely agree with the response by Dr. @Dr. First Last.

Gemcitabine/cisplatin and the recent addition of durvalumab based on TOPAZ-1 is typically well tolerated. Recent data from KEYNOTE-966 with gemcitabine/cisplatin and pembrolizumab suggested no new toxicity. In patients 75 and older and tho...