Topics:
Gastrointestinal Cancers • Medical Oncology • Geriatrics Oncology • Liver and Pancreas Tumors
What is the preferred palliative treatment regimen for elderly patients with advanced cholangiocarcinoma?
Answer from: Medical Oncologist at Academic Institution
There is very limited data to provide a data driven approach to the management of elderly patients with advanced cholangiocarcinoma. In my clinical experience, gem/cis combinational chemotherapy as given in the ABC-02 trial is well tolerated for most older adults with preserved performance status an...
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Answer from: Medical Oncologist at Academic Institution
I completely agree with the response by Dr. @Williams. Gemcitabine/cisplatin and the recent addition of durvalumab based on TOPAZ-1 is typically well tolerated. Recent data from KEYNOTE-966 with gemcitabine/cisplatin and pembrolizumab suggested no new toxicity. In patients 75 and older and thos...
Comments
Medical Oncologist at QMG Cancer Institute
Thank you, this is very helpful. For patients with...
Thank you, this is very helpful. For patients with...
Medical Oncologist at Mayo Clinic, Rochester
Following TOPAZ-1, the decision to shift to mainte...
Following TOPAZ-1, the decision to shift to mainte...
Medical Oncologist at QMG Cancer Institute
Thank you so much for the detailed answer!
Thank you so much for the detailed answer!