What is the preferred steroid regimen for metastatic prostate cancer patients on docetaxel?
Is there an optimal strategy to minimize unnecesary steroid use?
For example, pre-treatment dexamethasone or 3 day dexamethasone? Prednisone only continuously? Dexamethasone only continuously?
Answer from: Medical Oncologist at Academic Institution
TAX 327 (Tannock Et al NEJM 2004) used prednisone 5 mg bid in all patients (Q3 week Docetaxel and weekly Docetaxel). In addition, patients received dexamethasone 8 mg 3 times (12, 3, and 1 hour) before infusion. The prior phase 2 studies did not include prednisone with Docetaxel. Historically, low-d...
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