What is the role of PD-1 inhibitors in relapsed B-cell ALL?
What is the role of PD-1 inhibitors after CAR-T infusion, either as maintenance therapy or in the setting of relapsed disease?
1 Answer
Mednet MemberInvited Expert
Pediatric Hematology/Oncology · The University of Texas MD Anderson Cancer Center
Answered on
The role of PD-1 inhibitors in pedi is currently being explored in relapsed B-ALL in the study AALL1821. No interim results have been posted.
Primary samples from pediatric patients with relapsed B-ALL were shown to demonstrate marked up-regulation of PD-1 on T-cells, and up-regulation of PD-L1 on th...
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