What is the role of PD-1 inhibitors in relapsed B-cell ALL?

Topics: Hematologic Malignancies • Pediatric Oncology • Leukemia • ALL

What is the role of PD-1 inhibitors after CAR-T infusion, either as maintenance therapy or in the setting of relapsed disease?

Answer from: at Academic Institution

The role of PD-1 inhibitors in pedi is currently being explored in relapsed B-ALL in the study AALL1821. No interim results have been posted.Primary samples from pediatric patients with relapsed B-ALL were shown to demonstrate marked up-regulation of PD-1 on T-cells, and up-regulation of P...

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