What is the role of radiation treatment of stage IA ALK negative anaplastic large cell lymphoma?

Topics: Hematologic Malignancies • Radiation Oncology • Medical Oncology • Lymphoma • Hematology

PET/CT/bone marrow biopsy negative for evidence of distant disease. Following 4 cycles of combination chemotherapy with no evidence of progressive disease.

Answer from: Radiation Oncologist at Academic Institution

It would be helpful to know the site of origin. Most stage I ALCL alk neg would be in the skin, in which case RT is the treatment of choice with little role for chemotherapy. Stage I ALCL, other then skin, would be quite rare with no data to guide us, except that we know response to chemothera...

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Medical Oncologist at Tripler Army Medical Center
The site of origin was a single submental node. Th...

Medical Oncologist at Tripler Army Medical Center
This was a submental node. There was not skin invo...

Answer from: Medical Oncologist at Academic Institution

In patients with T-cell lymphoma, there is no good evidence to consider "short course" chemotherapy and therefore, it has been my practice to consider 6 cycles of chemotherapy for nodal stage IA ALK- ALCL followed by radiation as consolidation.

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