What is the role of SRS in the treatment of malignant gliomas?

This is a good question that has been formally studied. RTOG 93-05 was a negative phase III randomized trial of chemo-RT with or without an up-front SRS boost for glioblastoma. Results were published in the Souhami et al., PMID 15465203. Tumors had to be 4 cm or smaller to be eligible. Tumors were a...