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What is the role of surgery in patients with Stage III NSCLC and N2 positive lymph nodes?

Should surgery followed by adjuvant chemotherapy and radiation be considered for non-bulky single station N2 disease?
3 Answers
Mednet Member
Mednet Member
Radiation Oncology · Michigan Healthcare Professionals, PC
Answered on

Interestingly:

Patients that were to get lobectomy has survival of 2.8 years with surgery and 1.8 years with CRT

However, for pneumonectomy patients, patients treated with surgery had survival of 1.6 years while those treated with CRT had a survival of 2.4 years.

So.. patients with disease that see...

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Radiation Oncology · Quillen VA Medical Center
Answered on

We conceived and published a trial that published on this precise question. (Albain Lancel Oncology (2009) 374: 379-386). The simple answer is that there is no proven role for surgery in stage IIIa (or IIIb). The study used SWOG data and platforms; 45 Gy + Plat Etop pre-op or to "full dose" 61 Gy. T...

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Mednet Member
Mednet MemberInvited Expert
Radiation Oncology · Quillen VA Medical Center
Answered on

As the "cover story" of the exploratory analysis ran, there was an attempt to match factors of T, N and M; not specifically size, V-20, FEV1, or other clinically meanngfu; matter. Matched pair needs comparable matches to run more than one pass...there was very superficial "matches" in CRT subgroups;...

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