What is the safest approach to treating refractory RA in the setting of an active solid organ malignancy?

In order to best treat refractory RA in this patient with active solid malignancy who has failed rituximab, abatacept, and methotrexate, it is critical to understand their malignancy treatment options, prognosis as well as the patient’s goals of care. Traditional chemotherapy in certain types of solid malignancies may beneficially affect their articular disease and the use of prednisone alone for palliation may be appropriate until this effect can be assessed. Background DMARD least likely to af...