What is the utility and optimal timing of histologic conformation of NGGCT?  

ACNS1123 classified patients as NGGCT if serum & CSF AFP >10 ng/mL or bHCG >100 mIU/ml irrespective of biopsy results & did not mandate biopsy (although surgery was often performed in the setting of radiographic PR/SD/PD when markers normalized).

Do you still need to biopsy at diagnosis if the AFP is >10ng/mL or bHCG is >100mIU/ml, or can you defer unless there are radiographic or marker criteria for diagnostic/oncologic intervention following induction?

Are the present diagnostic thresholds appropriate or should a biopsy always be considered?



Answer from: at Academic Institution