What is the utility of granulocyte infusions in patients with neutropenia and severe infection?

Granulocyte transfusion is infrequently used for septic neutropenic patients given that the randomized trial (RING) that looked at this question did not show improved outcomes (with the caveat that the trial did not finish accrual (Price et al., PMID 26333778). Having said that, the criteria to consider are ANC <500 + evidence of bacterial or fungal infection + resistance to antimicrobial treatment for >48 hours + good probability of CBC recovery such as post alloSCT. The patient will need to be...