What is your approach for female patients with severe atopic dermatitis well controlled on Dupixent planning to conceive or already pregnant?

Based on published data, I have a few concerns. However, the clinical trials of Dupixent failed to study effects on learning and memory.

IL-4 and IL-13 are known to be important for learning and memory in mice. IL-4-producing T cells accumulate in the meningeal spaces, and acute depletion of these cells leads to impaired spatial learning and memory (Derecki et al., PMID 20439540). Meningeal-derived IL-4 maintains cognitive function. IL-13 has similar functions in mice 3 (Brombacher et al., PMID 2...

Dupixent is safe in pregnancy. I reassure the patient that they can stay on therapy if they want.