Topics:
Thoracic Malignancies • Medical Oncology
What is your approach for locoregional mediastinal recurrence of NSCLC adenocarcinoma in fit patients >5 years from definitive treatment (chemoradiation and/or surgery)?
Would this approach be different for a patient treated with tri-modality therapy (ie neoadjuvant chemoradiation followed by resection)?
Answer from: Medical Oncologist at Community Practice
There are a lot of variables here including number of lymph node stations involved, bulky vs non bulky disease, and lung/cardiac function. I would treat this similar to de novo diagnosis given the timeframe from prior treatment as this is unlikely to be an isolated relapse this far out. Definitive c...
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Answer from: Medical Oncologist at Community Practice
I would consider this a late relapse if same histology. Given the prior radiation therapy, I would think toxicity would be great from radiation.
I would treat this as recurrent disease, and depending on histology and PDL1 status use immunotherapy +/- chemotherapy unless adenocarcinoma PDL- in which...