What is your approach to adjuvant therapy for a fully resected (contained morcellation and laparoscopic removal), isolated retroperitoneal leiomyosarcoma in a patient with a remote history of a hysterectomy?

I would stage the patient with scans and I would check the resected LMS for estrogen receptor. A fair proportion of uterine LMS are ER+ and I think that is more likely to be true for a late recurrence.

If ER-negative, I would not give chemo with no disease to watch. Existing data from randomized clin...