Topics:
Breast Cancer • Medical Oncology
What is your approach to adjuvant therapy for patients with ER negative, PR positive early stage breast cancer?
Do you use anti-hormonal therapy for these patients?
Answer from: Medical Oncologist at Academic Institution
ER-negative but PR-positive is unusual (<5%) but not unheard of, and is worth repeating receptors to make sure is accurate. Assuming confirmed, given uncertainty about the nature of these tumors, I treat them as I do ER borderline (1-9%) tumors, with endocrine therapy but some skepticism ab...
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Answer from: Medical Oncologist at Community Practice
Does such an entity even exist? If it does, is it because of a false negative ER or a false positive PR? Does technical aspects of IHC staining influence the results? What would be the intrinsic subtype of the tumor? If it is luminal A/B, will anti-estrogen therapy matter in such patients? I ge...
Answer from: Medical Oncologist at Community Practice
Very small subset <5%. Some data suggests poorer prognosis for PR+/ER-. Because PR is an ER dependent protein product, we tend to be skeptic of true ER negativity, but it is possible that we may be seeing variation of expression within a tumor or technical issues.
If encountered, I would general...
Comments
Medical Oncologist at MOSC Medical College Kolenchery
Would you consider Intrinsic sub typing to assess ...
Would you consider Intrinsic sub typing to assess ...
Medical Oncologist at Private Practice and Digital Health
Very reasonable too.
Very reasonable too.
Radiation Oncologist at Center for Neurosciences
Dr.@Suleiman A. Massarweh - which data are yo...
Dr.@Suleiman A. Massarweh - which data are yo...