What is your approach to checking IgG levels post vaccination to detect common variable immunodeficiency in patients with systemic lupus?

Topics: Rheumatology • Systemic lupus erythematosus • IVIG • Vaccines

If a deficiency is present, do you consider IVIG to treat non-infectious symptoms such as skin rash, arthritis or hematological abnormalities?

Answer from: at Community Practice

I recommend that this type of workup for primary immunodeficiency disorders be done as soon as a diagnosis of systemic lupus erythematosus (SLE) is made. In other words, order quantitative immunoglobulins (IgA, IgM, IgG) plus IgG subclasses during your initial workup.Reasons being: Some primary imm...

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