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What is your approach to deprescribing gabapentinoids so as to prevent withdrawal effects?

1 Answer
Mednet MemberInvited Expert
Geriatric Medicine · University of California, San Francisco
Answered on · Updated on

Prescriptions for gabapentinoids are increasingly common, particularly for off-label indications such as neuropathic pain (1). There is relatively limited evidence to guide deprescribing strategies for gabapentinoids, as demonstrated in a 2023 scoping review (2). Abrupt discontinuation of gabapentinoids is generally discouraged as it may lead to withdrawal symptoms such as headache, dizziness, and insomnia (3). The package insert for gabapentin recommends that discontinuation should be done "gra...

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