What is your approach to diagnosis and management of Fanconi syndrome in pediatric patients receiving ifosfamide?

If Fanconi syndrome develops do you continue ifosfamide therapy?

• No, ifosfamide should be permanently discontinued and substituted as needed
• Temporarily discontinue and consider restarting if clinical improvement
• Yes, with dose reduction of ifosfamide
• Depends on patients underlying pre-existing renal impairment
• Other