What is your approach to first line systemic treatment for low risk gestational trophoblastic neoplasia?
Is there an optimal chemotherapy regimen that optimizes cure rates while minimizing side effects?
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What is your approach to first line systemic treatment for low risk gestational trophoblastic neoplasia?
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2 Answers
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Gynecologic Oncology · Froedtert Hospital, Medical College of Wisconsin
Answered on
Patients with gestational trophoblastic disease and a WHO score < 6 are classified as low risk. In patients who desire retention of fertility, the first line treatment is chemotherapy which achieves typically very high remission rates/cure rates. The most frequently used first line regimens employ m...
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Mednet Member
Gynecologic Oncology · Baptist Medical Group
Answered on
I use actinomycin D in patients with transportation issues (i.e., living out of town) since it is administered every two weeks. The remission rate is comparable to MTX.
These are remission data I found for low risk GTN treatment options:
- Methotrexate - 1 mg/kg IM day 1, 3, 5, 7. Folinic acid 0.1 mg...
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