What is your approach to locally advanced pancreatic cancer that has not progressed after neoadjuvant chemotherapy +/- chemoradiation but remains unresectable?  

As alluded to in the question stem, this is one of the only settings in which I consistently use XRT in the treatment of PDAC. I will also ensure that the patient has received both major chemo regimens (G/A and mFOLFIRINOX) if they are well enough to tolerate them (in case their cancer responds bett...