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Topics:
Hematologic Malignancies
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Medical Oncology
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Leukemia
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Hematology
What is your approach to management of relapsed/refractory T-cell prolymphocytic leukemia (T-PLL)?
For instance, after initial treatment with IV alemtuzumab, with or without pentostatin
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What is your preferred first-line treatment regimen for patients with high-risk MDS?
In patients with AML who achieve a CR with HMA/Ven, what is the optimal dose and schedule for venetoclax for further cycles?
In patients with post-PV myelofibrosis who are ineligible for allogeneic stem cell transplant, how do you approach symptomatic splenomegaly refractory to splenic radiation and ruxolitinib?
How would you approach a young, fit patient with suspected CNS involvement with high circulating blasts?
How do you manage ocular hemorrhages while on acalabrutinib for CLL?
Does treating CLL reduce the risk of non-melanoma skin cancers?
In patients with Philadelphia-negative ALL who are transplant ineligible, is there any data to guide the duration of maintenance POMP therapy?
What induction regimen would you consider for KMT2A-rearranged AML in a young patient with multiple medical co-morbidities who is ineligible for clinical trials?
How would you manage a patient with polycythemia and MPN symptoms (aquagenic pruritus, fatigue) that is JAK2/CALR/MPL negative but peripheral blood NGS positive for IDH2?
Would you give GO and/or a FLT3 inhibitor for patients with AML with t(8;21) and FLT3-ITD low in addition to 7+3?