What is your approach to the management of chronic GI bleeding from AVMs in an elderly patient on DOAC for atrial fibrillation?

I would definitely strongly consider the left atrial appendage occlusion device in these patients. While usually these devices (such as Watchman) do require anticoagulation for about 45 days until the device has an endothelial layer form on it (we usually confirm with a CT scan or TEE), there are so...

Watchman or other LAA occluders would be the best choice for stroke prevention if GI bleeding cannot be satisfactorily corrected, as can be the case with AVM’s. Watchman and Amulet don’t mandate anticoagulation immediately after implant. DAPT is an option in Watchman and the correct approach in Amul...

AVMs in a fragile elderly patient can be as life-threatening as AFib. There are several endoscopic, angiographic, surgical, and pharmacological procedures to treat and "cure" the condition. That possibility should be considered and discussed with the patient, besides LAAO obliteration/closure.

This suggests an elevated HAS-BLED score, making LAAO a reasonable option; post-LAAO DAPT may need to be truncated if post-implant TEE or CTA reveals a sealed LAA with adequate endothelialization.

Octreotide depot injections have worked well for some of my patients. Cost is definitely a concern, but I think there may be some coupons being offered to a select few patients by the pharmaceutical company itself. Requires some back and forth from the insurance company and the drug company.

I am a little different with these patients than previous responses. If we plug the LAA patients should really be on ASA long term, and we know from recent studies that ASA has similar bleeding to Eliquis. We do not know the effectiveness of LAAO devices without ASA. Therefore, I would consider no A...

There is evidence for thalidomide for recurrent GI bleeding from angiodysplasias (Chen et al., PMID 37913505). May be good to get a GI perspective on this use.