What is your approach to the monitoring and management of a never-smoker with respiratory symptoms and a nonspecific ventilatory pattern on pulmonary function testing?

In the RETHINC trial, inhaled dual bronchodilator therapy did not decrease respiratory symptoms in symptomatic tobacco-exposed people. We still do not know how best to address symptomatic people with PRISm or those with or without a smoking history and respiratory symptoms without obstruction on spi...