What is your approach to the use of denosumab in patients with metastatic breast cancer with bony involvement?
Do you extrapolate the results of OPTIMIZE-2 and CALGB 70604 showing that an every 12 week dosing of zolendronic acid is noninferior to every 3 weeks? If so, do you start this schedule with the first dose or after a "lead in" period?
1 Answer
Mednet Member
Medical Oncology · University of Texas MD Anderson Cancer Center
Answered on
I do not extrapolate the results of OPTIMIZE-2 and CALGB 70604 to denosumab. It is a different drug and until appropriate studies are performed, there is no reason to change its dose or schedule.
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