Topics:
Nephrology • Hypertension
What is your approach to thiazide diuretic use in those with uncontrolled hypertension and advanced chronic kidney disease?
Answer from: at Community Practice
The Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease (CLICK) trial provides an answer to this question. Chlorthalidone is still effective at lowering BP when eGFR is 15-30 mL/min/1.73m^2. Personally, I find it helpful to continue chlorthalidone in advanced CKD to help with kal...
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Answer from: at Academic Institution
I use thiazides to treat hypertension in dialysis patients, anuric or not. The drug’s mechanism of action has nothing to do with its diuretic properties; rather it appears to have an effect on endothelial sodium content and peripheral resistance. This became apparent many years ago when the st...