What is your approach to use of D-mannose for prevention of recurrent uncomplicated cystitis?
Especially in light of the results of the randomized clinical trial published on 8/2024 in Jama Internal Medicine by Hayward et al., PMID 38587819.
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What is your approach to the use of D-mannose for the prevention of recurrent uncomplicated cystitis?
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Infectious Disease · Massachusetts General Hospital
Answered on · Updated on
Unfortunately, in light of Hayward et al., PMID 38587819, I think there is a very limited role for the use of D-mannose for the prevention of recurrent uncomplicated cystitis. Our evidence-based options for the prevention of recurrent uncomplicated cystitis in postmenopausal women without catheters include vaginal estrogen therapy, increased fluids, methenamine, and antibiotic prophylaxis in carefully selected patients. Cranberry may also be an option.
Based on pre-clinical data highlighting the ...
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