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What is your current practice for obtaining mutation status for a patient with newly diagnosed ovarian cancer?

What specific platforms for determining somatic BRCA and HRD status do you use for a patient who does not carry a germline BRCA mutation?
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What is your practice for assessing mutation status in a patient with newly diagnosed ovarian cancer? (select all that apply)

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3 Answers
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Gynecologic Oncology · Center of Hope
Answered on · Updated on

My current practice is to test all newly diagnosed epithelial ovarian cancer patients (includes fallopian tube and peritoneal) with both germline multigene and somatic multigene/NGS panels. Only recently have I adopted the practice of concurrent testing at diagnosis rather than basing the decision t...

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Medical Oncology · University of Utah School of Medicine
Answered on · Updated on

All ovarian patients at our center get referred for comprehensive genetic testing (to look for germline mutations). Some of these platforms will reflex negative germline testing to somatic testing.

If that is not done in a particular case, then we will send tissue for Myriad MyChoice testing to obta...

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Gynecologic Oncology · UCSD Moores Cancer Center
Answered on

Currently, patients with newly diagnosed epithelial ovarian cancer undergo germline genetic testing using the Myriad MyRisk platform. This allows for integrated reflex testing with Myriad MyChoice (in the context of negative gremline BRCA testing), capturing somatic BRCA, as well as HRD status. In p...

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