What is your cut off on ER percent positivity to treat breast cancer as functional triple negative cancer?

Topics: Breast Cancer • Medical Oncology • HR+ • Breast Cancer, Non-metastatic

Do you take PR percent into account?

Answer from: Medical Oncologist at Community Practice

I usually use less than 10% ER positivity as the cut off. In this case, I would treat as if the tumor is TNBC.

Comments

Medical Oncologist at MD Anderson Cancer Center
I agree. 10% or less should be treated as TNBC. In...

Medical Oncologist at NYU Winthrop Hospital
NCCN Guidelines- <1% is ER negative. 1-...

Medical Oncologist at Banner MD Anderson Cancer Center
The question was on the functional definition of T...

Medical Oncologist at NYU Langone Medical Center
Important point!

Medical Oncologist at Providence Health Care
Very important point

Answer from: Medical Oncologist at Community Practice

The answer is dependent on the setting: Neoadjuvant (biopsy alone used to determine ER/PR): I sometimes place patients as high as ER 20-30% on KEYNOTE 522. Often, I seek a second opinion on ER/PR IHC in these settings, as I have had cases of false positives at my local institution. Adjuvant...

Comments

Medical Oncologist at UC Davis Comprehensive Cancer Center
Just clarifying, Dr. @Imam. Is there good data to ...

Medical Oncologist at Florida Cancer Specialists and Research Institute
Thank you @Rashmi, I would agree with you, there a...

Medical Oncologist at NYU Winthrop Hospital
KEYNOTE 522: Patient should be triple neg, not 10%...

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