What is your first line of therapy for refractory Hodgkin lymphoma in an AYA patient?

Our first approach in this setting is second line chemotherapy with the intention to achieve a complete metabolic remission (by PET) and then an autologous stem cell transplant. Our approach to the transplant includes total lymphoid irradiation followed by a conditioning regimen of Cyclophosphamide,...

If a patient has already received cumulative doxorubicin 400 mg/m², is it safe for him to receive liposomal doxorubicin as part of Pem-GVD?