What is your local control approach to localized relapse of Ewing sarcoma in a site that was previously unresectable and received definitive radiation?

It depends obviously on some other factors including disease-free interval, the site itself, the dose of radiation received, symptoms, etc...

Generally, a combined modality approach is attempted. Second-line chemotherapy with either high-dose ifosfamide, irinotecan/temozolomide, or topotecan/cycloph...