What is your pharmacological approach to treating depressive disorders in patients who develop serotonin toxicity?

I would try bupropion. Not Auvelity, as dextromethorphan has serotonergic activity. I would want to see if they were on any medication other than psychiatric that contributed to serotonin syndrome, like tramadol, and get rid of that or replace it as needed. I would probably want to transition to a n...

I would first review all the medications that the patient is on to assure myself that he is not taking any other medications that interact with serotonin receptors. If the patient still needs treatment for depression and is not suicidal, then I would recommend therapy, improvement of sleep hygiene, ...

Great answers above.

If nothing else works or there is no safe alternative, ECT should be seriously considered.