What is your preferred chemotherapy regimen to give concurrently with radiation for unresectable stage 3 NSCLC?

I have generally preferred the cisplatin/etoposide regimen, in part due to the "consolidation" portion of the weekly paclitaxel/carboplatin regimen (ie in patients who could tolerate cisplatin based regimen, it seems preferable to be done after six weeks rather than 12 weeks). That being said, I do ...

I prefer the regimen of weekly low dose carboplatin (AUC = 2) and paclitaxel (45-50 mg/m2) x 6 with concurrent radiotherapy to 60 Gy followed by two cycles of consolidation carboplatin (AUC = 5-6), paclitaxel (200 mg/m2). This regimen has been extensively employed. The results of the RTOG 0617 trial...

If possible, I use cisplatin and etoposide. If no progression, add durvalumab subsequently. Having said that, if a patient's renal function or KPS are an issue then I have used weekly carbo taxol. I discuss two cycles of consolidation and then add durvalumab if no progression.

There is a discussion about this topic in the era of PACIFIC which can be found here.