What is your preferred conditioning regimen for fit patients with high-risk MDS undergoing MUD allogeneic stem cell transplantation?

The short answer is whatever MAC regimen you and your center are familiar with and comfortable managing the side effects. I would definitely think of a myeloablative regimen rather than a reduced intensity one. For HLA-matched donor, I usually give MAC Bu4Flu with Bu PK to tailor the Bu dose.

The BM...