New: NCI-funded clinical trial search
Mednet Logo

What is your preferred dose-fractionation regimen for cT1-T2N0 oropharynx treated with radiation alone?

Is conventional fractionation acceptable, or would you use altered fractionation (DAHANCA, SIB, BID etc.)?
1 Answer
Mednet Member
Radiation Oncology · Michigan Healthcare Professionals, PC
Answered on

The results from RTOG 0022 showed very high local control and low salivary toxicity with moderately accelerated hypofractionation SIB.

They gave 2.2 Gy x 30 fractions (66 Gy) to gross disease, and 1.8 Gy (54 Gy) to lower risk areas and achieved <10% LF at 2 years. 7 patients failed, but 2 of them had PTVs that were unacceptablyunderdosed, receiving less than 95% of prescription. 15-16% experiencing grade 2 toxicity at 18-24 months (none with grade 3). These results compare favorably with historical controls treated with conventional fractionation (that had higher proportions of HPV negative patients), and have similar results with series treated with IMRT in the modern era.

This scheme allows completion in 6 weeks, which is the same length ...

Join for free or sign in to see the full answer