What is your preferred first line therapy in well differentiated GI NET with Ki67 > 55%?
Does DOTATATE scan results/burden of disease change your preference?
Answer from: Medical Oncologist at Academic Institution
Without much detail provided here, I think understanding the biological behavior of this tumor is a key detail. For more indolent biology, you can use everolimus or SSA therapy, for example. For more aggressive disease, you would lean toward cape/tem, etoposide/platinum, or FOLFOX. An excellent trea...
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Answer from: Medical Oncologist at Community Practice
NET with > 55% Ki-67 is more likely to behave like a poorly differentiated tumor/NEC. This can be further confirmed by lack of DOTATATE uptake, avid FDG uptake, and mutations such as p53 and Rb. ATRX/DAXX and MEN1 will mean a grade 3 well differentiated, in which case capecitabine/temozolomide wi...