What is your preferred frontline regimen for metastatic unresectable fibrolamellar carcinoma in an AYA patient?

We have successfully used GEMOX-LEN along with multidisciplinary locoregional tumor debulking to convert more than 50% of unresectable stage IV FLC to definitive R0 resection and surgical remission, nearly 100% achieving 0.00 circulating tumor DNA (we use Signatera):

• Ginters et al., GI Cancer Trial...