What is your preferred induction chemotherapy for stage IIIA NSCLC squamous and adenocarcinoma?

I approach induction therapy for locally advanced disease in a similar way to adjuvant chemotherapy, and use many of the same regimens. For adenocarcinoma, I prefer a pemetrexed-based regimen–cisplatin or carboplatin depending on age and co-morbidities. I avoid bevacizumab in these patients if surgery or radiation is a potential option, due to increased risk of complications.

For squamous cell carcinoma, I favor either carboplatin-paclitaxel (well-tolerated and can easily be transitioned to a chemoradiation regimen, if not a surgical candidate after induction) or platinum-gemcitabine. If radiation is a potential option, I avoid gemcitabine.

There are ongoing clinical trials of immunotherapy for induction, but I am not using these regimens o...