Clinical trials, e.g. ICONIC (PI: Dr. Andrea Apolo) would be very interesting if slots are available. Outside trials, would consider FOLFOX (or FOLFIRI if neuropathy is an issue) as a 'colorectal-like' regimen (GI Med Onc can help manage regimen based on their experience). Dr. Siefker-Radtke had a t...

Given the absence of high level evidence (and the likelihood we will never have high level evidence), I would extrapolate from colorectal cancer and suggest FOLFOXIRI-bevacizumab in a fit patient (similar to advanced colorectal cancer). In those with suboptimal performance status or comorbidities, c...