What is your preferred salvage chemotherapy regimen for bridge to auto SCT for patients with relapsed classical Hodgkin Lymphoma?
There are multiple regimens including IGEV and most recently reported results of BEGEV without preference on NCCN guidelines.
2 Answers
Mednet Member
Medical Oncology · Rutgers Cancer Institute of New Jersey
Answered on
We actually have been favoring using a bendamustine-brentuximab based regimen (in those who have not received brentuximab in the front line setting). Supportive data is based on Lancet Oncol. Feb 2018 that showed a favorable toxicity profile with an almost 80% ORR.
Usually will give 2-3 cycles, rest...
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Mednet MemberInvited Expert
Medical Oncology · University of Maryland Cancer Center
Answered on
Honestly, the most important point is to achieve CMR on PET/CT before AutoSCT, rather than how to achieve it. Brentuximab vedotin-based regimens (if not received in 1L treatment) are mostly used as single agent or in addition to bendamustine.
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