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What is your preferred stain for melanocytic lesions?

SOX-10, MITF, PRAME, S100, etc?
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What is your preferred stain for melanocytic lesions?

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1 Answer
Mednet Member
Mednet MemberInvited Expert
Dermatology · UC Davis Health
Answered on

Our lab uses all the listed stains. Which one(s) depends on context + question. Results will inevitably vary between labs. Currently, PRAME and SOX-10 are our two most popular.

  1. Nevus vs melanoma. PRAME, as an ancillary diagnostic test.
  2. Definitive confirmation of melanocytes (vs non-melanocytes) bey...

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