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Medical Oncology • Immune-related adverse events • Rheumatology • Neurology • Pulmonology • Dermatology • Gynecologic Oncology • Multispecialty Spotlight
What is your preferred steroid sparing therapy in a patient experiencing a severe checkpoint inhibitor toxicity and not responding to high dose IV steroids?
Answer from: at Community Practice
There are likely two different questions here:
1) For patients who have responded to steroids, but are unable to taper off (or to a minimally acceptable chronic dose), I have favored mycophenolate as a steroid sparing agent.
2) For patients with severe pneumonitis that is refractory to stero...
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Answer from: at Academic Institution
This is a situation that needs to be tailored on an individual basis, especially taking into account the underlying cancer type. I prefer IL-6 inhibitors if the underlying malignancy is melanoma and no other contraindications exist for their use.
In someone with a solid cancer, I might consider TNF...