What is your preferred TKI and dosing for AYAs or adult patients with Ph+ ALL?

We typically follow the MD Anderson updated approach of adding dasatinib 100mg daily for first 2 weeks in cycle 1 and then 70mg daily starting cycle 2 (Cancer 2015; 121:4158).

How long to continue? That’s a tough one with essentially no mature data. The COG study continued for only 2 years, though da...